6－0－丙酰基日本杜鹃素Ⅲ的合成

Synthesis of rhodojaponin Ⅲ 6-propionate

目的：定位合成６－Ｏ－丙酰基日本杜鹃素Ⅲ，评价其毒性。方法：以日本杜鹃素Ⅲ为原料合成目标物，用小鼠测定ＬＤ５０。结果：获得目标物并测得ＬＤ＿（５０）＝２．５１ｍｇ／ｋｇ（可信限２．０～３．１９）。结论：日本杜鹃素Ⅲ经６－Ｏ－丙酰化后，毒性降低５倍。

OBJECTIVE:To synthesize the rhodojaponin Ⅲ 6-propionate and evaluate its toxicity,METHOD:We used rhodojaponin Ⅲ as raw material and mice as experimental animals。 RESULTS:The title compound and itsLD50=2.5l mg/kg(confidence limit is 2.0～3. 19)were obtained.CONCLUSION The toxicity of rhodojaponin Ⅲ6-propionate is five times smaller than that of rhodojaponin Ⅲ.