鼻息肉与端粒酶活性的相关性研究

Activity of telomerase in nasal polyp tissues

目的:探讨端粒酶活性在鼻息肉组织中的表达及其临床意义。方法:采用免疫组织化学法(PV-9000二步法)检测40例鼻息肉标本及10例健康者下鼻甲黏膜标本的端粒酶活性(端粒酶催化亚基蛋白hTERT)的表达。结果:健康者下鼻甲黏膜端粒酶活性表达均为阴性,鼻息肉组织端粒酶活性表达阳性率为82.5%,差异有统计学意义。端粒酶活性表达与鼻窦炎伴鼻息肉的临床分型、分期无相关性,与鼻息肉的复发呈正相关。结论:端粒酶活性与鼻息肉的发生发展密切相关,检测端粒酶活性对临床预测鼻息肉复发倾向有一定意义。

Objective： To investigate the expression of telomerase activity and human telomerase reverse transcriptase（hTERT） in the nasal polyp tissues and their significance. Method： The expression of hTERT of 40 cases of nasal polyp tissues and 10 cases of normal inferior turbinate tissues was detected by immunohistochemical staining （PV- 9000 two-step kit）. Results： The expression of telomerase in normal inferior turbinate tissues and nasal polyp tissues was 0 and 82.5%, respectively, and the difference was significant. The expression of telomerase had no significant correlation to the tumor grade, but had close correlation to the recurrence. Conclusion： The expression of telomerase is closely related with nasal polyp progression. It could be postulated that telomerase activity could be related with the tendency of polyp to recur.