2Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue [ J ]. Nature, 1994, 372 ( 6505 ) :425-432.
3Isse N, Ogawa Y, Tamura N , et al.Structural organization and chromosomal assignment of the human obese gene[J]. J Biol Chem, 1995, 270(17) : 27728-27733.
4J Ren. Leptin and hyperleptinemia from friend to foe for cardiovascular funetion [J]. J Endocrinology, 2004, 181(1): 1-10.
5Collins S, Kuhn CM, Petro AE, et al. Role of leptin in fat regulation [J]. Nature, 1996, 380(6576):677-683.
6Schutte R, Huisman HW, Schutte AE, et al. Leptin is independently associated with systolic blood pressure, pulse pressure and arterial compliance in hypertensive African women with increased adiposity : the POWIRS study [J]. J Hum Hypertens, 2005, 19(7) :535-541.
8Al-Hazimi AM, Syiamic AY. Relationship between plasma angiotensinII,leptin and arterial blood pressure[J]. Saudi Med J, 2004, 25(9):1193-1198.
9Iwashita S, Tanida M, Terui N, et al. Direct measurement of renal sympathetic nervous activity in high-fat diet-related hypertensive rats[J]. Life Sci ,2002, 71(5):537-546.
10Golan E, Tal B, Dror Y, et al. Reduction in resting metabolic rate and ratio of plasma leptin to urinary nitric oxide: influence on obesity-related hypertension[J]. Isr Med Assoc J, 2002, 4(6) : 426-430.
6Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood presure: the JNC- 7 [J]. JAMA, 2003, 289, 2560-2572.