加味五子衍宗颗粒对轻度认知障碍患者记忆功能及海马体积的磁共振研究

Effects of Modified Wuzi Yanzong Granule on Memory Ability and Volume of Hippocampus Measured by MRI in Patients with Mild Cognitive Impairment

目的观察加味五子衍宗颗粒对轻度认知障碍(mild cognitive i mpairment,MCI)患者记忆功能及磁共振定量海马体积的影响。方法参照目前国际公认的MCI诊断标准,筛选出36例MCI患者,采用随机双盲分组,分为加味五子衍宗颗粒治疗组(简称治疗组18例)和安慰剂对照组(简称对照组18例),服药3个月,观察用药前后记忆功能及MRI定量海马体积的变化。另选20名健康人为正常对照组(简称正常组)。结果MCI患者的记忆商(MQ)较健康人明显降低(P<0·01)。用药后,治疗组的MQ较其用药前明显提高(P<0·01),且较对照组治疗前后MQ的差值有明显提高(P<0·05);治疗组海马总体积及左、右侧海马体积均较对照组有明显提高(P<0·05),海马总体积的差值较对照组亦有明显提高(P<0·05)。结论加味五子衍宗颗粒能改善MCI患者的记忆功能,对海马体积的萎缩有一定的防治作用。

Objective To observe the effect of modified Wuzi Yanzong Granule （WYG） on memory ability and volume of hippocampus measured by magnetic resonance imaging （MRI） in patients with mild cognitive impairment （MCI）. Methods According to the international accepted diagnostic criteria, 36 MCI patients were selected and randomly assigned to two groups equally, the treated group treated with WYG and the control group with placebo, with a course of 3 months for both groups. Besides, 20 healthy subjects were selected as the normal group. The changes of memory ability were observed and the volume of hippocampus was detected by MRI before and after treatment. Results Memory quotient （MQ） was significantly lower in MCI patients than in healthy subjects （P〈 0.01）, after treatment it increased in the treated group as compared with that before treatment （P〈0.01）, and the increment was higher than that in the control group （P〈0.05） ; the volume of hippocampus, total or that of either side, as well as the increment of the total volume of hippocampus in the treated group were all higher than those in the control group （P 〈 0.05）. Conclusion WYG could improve memory ability in MCI patients and could prevent and treat the hippocampal atrophy to certain degree.