甘草对雷公藤治疗类风湿关节炎的减毒增效作用

Toxicity Attenuation and Efficacy Potentiation Effect of Liquorice on Treatment of Rheumatoid Arthritis with Tripterygium Wilfordii

目的探讨甘草对雷公藤治疗类风湿关节炎(rheumatoid arthritis,RA)减毒增效作用。方法将120例确诊RA患者随机分为两组,治疗组在单用或在原治疗方法基础上加甘草雷公藤复方煎剂治疗,对照组在单用或原治疗方法基础上加等效剂量雷公藤多甙片治疗,观察两组治疗2个月后疗效和不良反应发生率。结果治疗组和对照组总有效率分别为89.8%和79.6%,组间比较差异无显著性。治疗组关节肿胀指数下降、双手平均握力升高优于对照组(P<0.05);治疗组的不良反应总发生率明显低于对照组(P<0.01)。结论甘草对雷公藤治疗RA有减毒增效作用。

Objective To investigate the toxicity attenuation and efficacy potentiation effect of liquorice on treatment of rheumatoid arthritis （RA） with tripterygium wilfordii （TW）, Methods One hundred and twenty RA patients were randomly assigned to two groups： the treated group treated with compound decoctum of TW and liquorice and the control group with TW ployglycosidium tablets both based on routine treatment, The therapeutic effect and adverse reaction were observed after 2 months of treatment. Results The total efficacy rate was 89.8% in the treated group and 79.6 % in the control group with insignificant difference between the two groups; the effect was better in the treated group than that of the control group in decreasing the swollen joint index and increasing the average grip strength of both hands （P ~ 0.05） ; the total incidence of adverse reaction was obviously lower in the treated group than that of the control （P〈0.01）. Conclusion Liquorice has toxicity attenuation and efficacy potentiation effect on treatment of RA with TW.