针刺脑反应的功能性磁共振成像研究——附14名健康人资料观察

Study on Brain Response to Acupuncture by Functional Magnetic Resonance Imaging——Observation on 14 Healthy Subjects

目的利用功能性磁共振成像(f MRI)观察针刺3条不同经络的穴位(三阴交、足三里和阳陵泉)所引起的脑功能区的信号变化,对针刺的神经机制作初步探讨。方法对14名健康志愿者进行针刺f MRI,每次磁共振扫描持续5min12s;手法行针30s,静息30s,然后再重复相同的刺激模式,如此反复交替,直至试验结束。结果(1)针刺足三里、三阴交穴相同的脑部激活区为中央后回及右侧额下回;不同的激活区为左额下回、左岛叶、左侧顶下小叶、左小脑山顶、左颞中回及左额中回。针刺阳陵泉穴未发现大脑皮层的信号增高区。(2)针刺3条不同经络的3个不同的穴位均可以出现脑部信号减低区,其共同的区域见于双侧海马旁回、海马、扣带回、楔前叶及小脑。结论针刺不同的穴位可以在脑部特定的区域产生效应。

Objective To observe the signal changes of brain functional area during needling Sanyinjiao （ST36）, Zusanli （SP6） and Yanghngquan （GB34）, the three acupoints in three different meridians, in human by functional magnetic resonance imaging （flVIRI）, in order to preliminary explore the neural mechanism of acupuncture. Methods Needling was complemented with 30 s of maneuver applying followed by 30 s of rest as a circle on an acupoint, and at the same time, fMRI was performed once 5 min and 12 s. Then the same program was repeated with the same mode on another acupoint, until ending the experiment. Results The commonly activated regions were postcentral gyrus and right inferior frontal gyrus when needling at ST36 and SP6, and the different activated areas included left inferior frontal gyrus, left insula, left inferior parietal lobule, left culmen, left middle temporal gyrus and left middle frontal gyms, while no cortical signal enhanced region was found when needling at GB34. Signal weakened regions could be found when needling at all the three points, the commonly activated regions were bilateral parahippocampal, hippocampal, callosal gyrus, bilateral praecuneus and cerebellum. Conclusion Brain response in special regions could be obtained by needling at different acupoints.