芪地益气养阴活血方治疗Ⅲ、Ⅳ期糖尿病肾病的临床观察

Clinical Observation on Qidi Yiqi Yangyin Huoxue Recipe in Treating Diabetic Nephropathy at Stage Ⅲ and Ⅳ

目的探讨芪地益气养阴活血方对糖尿病肾病的临床疗效。方法选择2型糖尿病肾病(Ⅲ、Ⅳ期)气阴两虚夹瘀证患者100例,随机分为两组,两组降糖治疗基本相同,治疗组同时给予芪地益气养阴活血方治疗3个月,观察两组疗效、治疗前后血糖、尿白蛋白排泄率、尿素氮、肌酐及血液流变学等指标。结果总有效率治疗组(89·6%)优于对照组(68·1%,P<0·01),治疗组在改善尿白蛋白排泄率、肌酐、尿素氮及血液流变学指标等方面均显著优于对照组(P<0·05)。结论芪地益气养阴活血方治疗气阴两虚夹瘀型2型糖尿病肾病有较好的疗效。

Objective To observe the clinical effect of Qidi Yiqi Yangyin Huoxue Recipe （QYYHR） on diabetic nephropathy （DN） at stage Ⅲ and Ⅳ. Methods One hundred type 2 DN patients of qi-yin deficiency with blood-stasis syndrome were randomly divided into two groups, all were treated with basal hypoglycemic treatment but with QYYHR given to the treatment group additionally for 3 months. The symptoms were observed, blood glucose, urinary albumin excretion rate （UAER）, blood urea nitrogen （BUN）, creatinine （Cr） and hemorheological parameters were detected before and after treatment. Results The total effective rate was higher in the treatment group than that in the control group （89.6 % vs 68.1% , P〈 0.01）, and the improvement of UAER, BUN, Cr and hemorheological parameters was also significantly better in the former than in the latter （P〈0.05）. Conclusion QYYHR has favorable effects on type 2 DN of qi-yin deficiency with blood-stasis syndrome.