COX-2和VEGF在人脑星形细胞瘤中的表达及与临床病理分级的相关性

Expression of COX-2 and VEGF in human astrocytomas and its relations with pathological grades

目的探讨环氧化酶-2(COX-2)和血管内皮生长因子(VEGF)在人脑星形细胞瘤中的表达及其与肿瘤临床病理分级的关系。方法通过免疫组化SP法测定COX-2和VEGF在50例人脑星形细胞瘤和10例正常脑组织中的表达。结果COX-2、VEGF在人脑星形细胞瘤中的表达高于正常脑组织(P<0.001)。COX-2和VEGF与人脑星形细胞瘤临床病理分级显著相关(P<0.05)。人脑星形细胞瘤中COX-2与VEGF的表达存在相关性。结论COX-2和VEGF参与人脑星形细胞瘤的发生、发展且与其恶性表型有关;COX-2可能与人脑星形细胞瘤的血管形成有关。

Objective To investigate the expression of cyclooxygenase-2 （COX-2） and vascular endothelial growth factor （VEGF） and their relationships with the pathological characteristics of human astrocytomas. Methods Im＇- munohistochemistry method was used to investigate the expression of COX-2 and VEGF among human astrocytoma samples （n =50） and normal brain tissue （n =10） respectively. Results The positive rate of COX-2 and VEGF was different between the human astrocytomas and normal brain tissue （ P 〈 0. 01 ）. The expression of COX-2 in human astrocytomas was related to the tumor＇s pathological grades （ P 〈 0. 05 ）. The expression of VEGF was closely associated with COX-2 （P 〈0. 01 ）. Conclusions COX-2 and VEGF may be involved in gliomas＇ occurance and development. Expression of COX-2 and VEGF protein Was positively correlated with malignant phenotype of gliomas.