维生素C联合葛根素治疗早期2型糖尿病肾病的疗效观察

Observation of Vitamin C Combined with Injection Puerarin on Therapeutic Effect in Treatment of Type 2 Diabetic Nephropathy

目的:观察葛根素注射液联用维生素C对2型糖尿病肾病的治疗作用。方法:将确诊为2型糖尿病肾病的100例患者随机分为治疗组52例,给予葛根素注射液500mg/天,加用口服维生素C 0.3g,3次/天;对照组48例,单用葛根素,两组葛根素均静脉滴注,均以2周为1个疗程。观察2组治疗前后的UAER、BUN、SCr等指标的变化。结果:治疗组治疗后上述各项指标与治疗前均显著改善(P<0.05或P<0.01)。结论:葛根素注射液有较好的改善肾功能及降低尿蛋白排泄率的作用。葛根素注射液加用维生素C治疗2型糖尿病肾病的疗效比单用葛根素好,两者有协同作用。

Objective： To observe vitamin C combined with injection puerarin on therapeutic effect in treatment of diabetic nephropathy. Methods： 100 patients with type 2 diabetic nephropathy randomized into the treatment group （41eases） and the control group （37cases） the control group were treated with injection puerarin 500mg· d^-1 iv,gtt, qd,and the treatment group received the same medicine combined with vitamin C 0.3g, pe, tid ,both groups were treated for 2 weeks, the parameters of blood plasma such as blood urea nitrogen,sertun creatinine,urinary albumin excretion rate were tested before and after the treatment. Results： In the treatment group,the average value of the tested parameters were decreased signifcantly after the treatment than before the treatment （P 〈 0 05 or P 〈 0 01 ）, the average value of the tested parameters were also lowered significantly in the treatment group than in the control group（ P 〈0 05 orP 〈0 01） . Conclusion ：Injection puerarin can lower the blood urea nitrogen,serum creatinine ,improve renal function, and decrease urine protein the combination of injection puerarin with vitamin C has better effect than injection puerarin alone in treatment of type 2 diabetic nephropathy .