CD44和CD54在大肠癌患者外周血的表达及临床意义

Expression and Clinical Significance of CD44 and CD54 in Peripheral Blood of Patients with Colorectal Cancer

目的探讨大肠癌患者外周血细胞CD44、CD54的表达及临床意义。方法采用流式细胞术对40例大肠癌患者及20例良性病变组、20例正常对照组外周血细胞CD44、CD54的表达水平进行检测。结果大肠癌患者外周血细胞的CD44、CD54的表达水平均显著高于良性病变组及正常对照组,P<0.05;且大肠癌患者外周血细胞中CD44和CD54的表达水平与淋巴结转移和临床分期相关;良性病变组与正常对照组的比较无显著性意义。结论CD44及CD54在外周血的表达与肿瘤转移密切相关,检测大肠癌患者外周血中的CD44及CD54的表达可为肿瘤的发生、发展及预后判断提供依据。

Objective To investigate the expression and clinical significance of CD44 and CD54 in peripheral blood of patients with colorectal cancer. Methods The levels of CD44 and CD54 in peripheral blood cell from 40 patients with colorectal cancer and 20 benign cases and 20 normal control cases were measured by the flow cytometry. Results The levels of CD44 and CD54 in peripheral blood cells of patients with colorectal cancer were significantly higher than those of benign cases and normal control, P 〈 0. 05, and the levels of CD44 and CD54 in peripheral blood cells of patients with colorectal cancer were correlated with the metastases of lymph node and the stages of clinic ; While the comparison of the levels of CD44 and CD54 in peripheral blood cells between benign cases and norreal control cases was not prominently significant. Conclusion The levels of CD44 and CD54 in peripheral blood cells of patients with colorectal cancer are closely related to tumor metastases, so the detection of CD44 and CD54 can provide significant evidences for the development and prognosis of colorectal cancer.