慢性肾衰患者促红细胞生成素与血红蛋白的相关性研究

Study of Correlation between Serum Erythropoietin and Hemoglobin in Anemic Patients of Chronic Renal Failure

目的探讨慢性肾衰(CRF)贫血患者血清促红细胞生成素(sEPO)与血红蛋白(Hb)的关系。方法20例慢性肾衰贫血患者,采用放射免疫法测定其血清促红细胞生成素(Serum erythropoietin,sEPO)的水平,分析sEPO与Hb的相关性;同时以缺铁性贫血(IDA)患者的sEPO对贫血的反应作为贫血状态下sEPO对Hb正常相关关系的对照,测定20例IDA患者的sEPO,并进行相关回归分析。结果20例慢性肾衰贫血组的sEPO水平明显低于IDA患者(P<0.001)。慢性肾衰贫血组及IDA组的Hb与sEPO均呈明显的直线负相关关系(r IDA=-0.458,PIDA<0.005;rCRF=-0.226,PCRF<0.05)。慢性肾衰贫血组Hb-sEPO回归直线的斜率(bCRF=-0.0123)与在Y轴上的截距(aCRF=1.98)均小于IDA组(bIDA=-0.0183,aIDA=2.797)。结论慢性肾衰贫血患者普遍存在sEPO相对缺乏,表现为sEPO对贫血反应迟钝。

Objective To study the correlation between the serum erythropoietin （sEPO） and hemoglobin（Hb） in anemic patients of chronic renal failure （CRF）. Methods The serum EPO was evaluated by radioimmunoassay in 20 anemic CRF patients and 20 iron deficiency anemia （IDA） patients and the relativity with sEPO and haemoglobin （Hb） level was analysed. The IDA patients was used as a control group on the normal response of sEPO to Hb and the regression analysis was used to get linear equation about it. Results sEPO levels in anemia of CRF patients were lower than those of IDA patients（ P 〈0. 001 ）. There was a significant linear correlation between Hb and sEPO in anemic CRF patients and in IDA patients（ rCRF = - 0. 226, P 〈 0. 05 ; rlDA = - 0. 458, P 〈 0. 005 ）. Regression coefficient （ bCRF = -0. 0123 ） and Y - intercept（ aCRF = 1.98 ） of anemic CRF patients were both lower than that of IDA patients（ bIDA = - 0. 0183, aIDA = 2. 797 ）. Conclusion sEPO level is relatively deficient in anemia of CRF.