期刊文献+

美托洛尔对急性心肌梗死后心室重构及心功能的影响 被引量:1

下载PDF
导出
摘要 目的 观察β-受体阻滞剂美托洛尔对急性心肌梗死后心功能及心室重构的影响。方法 选择2000年2月-2004年8月本院收治的急性心肌梗死患者39例,其中男性23例,女性16例。在急性心肌梗死常规治疗基础上给予美托洛尔口服,从小剂量开始,依病人耐受性,逐渐增加剂量,目标剂量(50—100)mg/d,总疗程1年。分别于治疗前、后20用超声心动图、心电图、血液生化检查,了解心脏功能与心脏结构变化以及肝肾功能。结果 治疗后20用与治疗前比较心功能改善、心室重构逆转均达统计学意义(P〈0.01)。结论 美托洛尔可逆转急性心肌梗死患者心室重构并有效改善心功能。
作者 马志平
出处 《中原医刊》 2007年第2期83-83,共1页 Central Plains Medical Journal
  • 相关文献

参考文献4

二级参考文献13

  • 1Nahrendorf M, Hu K, Fraccarollo D, et al. Time course of right ventricular remodelling in rats with experimental myocardial infarction. Am J Physiol Heart Circ Physiol,2003, 284:H241-H248.
  • 2Willenheimer R. Left ventrivular remodelling and dysfunction. Can the process be prevented? Int J Cardiol, 2000, 72,143-150.
  • 3Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium: fibrosis and rennin-angiotensin-aldosterone system. Circulation, 1991,83: 1849-1865.
  • 4Kaikita K, Hayasaki T, Okuma T, et al. Targeted deletion of CC chemokine receptor 2 attenuates left ventricular remodeling after experimental myocardial infarction. Am J Pathol, 2004, 165: 439 - 447.
  • 5Bolognese L,Carrabba N,Parodi G, et al. Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction. Circulation, 2004,109: 1121 - 1126.
  • 6Nguyen Q, Colombo F, Clement R, et al. AT1 receptor antagonist therapy preferentially ameliorated right ventricular function and phenotype during the early phase of remodeling post -MI. Br J Pharmacol,2003, 138:1485-1494.
  • 7Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on mortality and morbidity in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med,1999,341: 709-717.
  • 8Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker , in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med,2003,348: 1309-1321.
  • 9Tavazzi L.GISSI-3:long-term follow-up,Presented at the 20th Congress of Cardiology,August 22-26,1998,inVienna,Austria.Circulation,1999,99(9):1127-1131.
  • 10ISIS-4(Fourth International Study of Infarct Survival) Collaborative Group.ISIS-4:a randomized factorial trial assessing early oral Captopril,oral mononitrate,and intravenous magnesium sulfate in 58050 patients with suspected acute myocardial infarction[J].Lancet,1995,345(8951):669-685.

共引文献4954

同被引文献8

  • 1Landmesser U, Wollert K C, Drexler H. Potential novel pharmacological therapies for myocardial remodelling[J]. Cardiovasc Res,2009 ,81:519.
  • 2Jugdutt B I. Matrix metalloproteinases as markers of adverse remodeling af- ter myocardial infarction[ J]. Card Fail,2006,12 ( 1 ) :73.
  • 3Weir R A, Mark P B, Petrie C J, et al. Left ventricular remodeling after acute myocardial infarction: does eplerenone have an effect [ J ]. Am Heart J,2009,157 (6) : 1088.
  • 4Pitt B, Zannad F, Remme W J, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators[ J]. N Engl J Med, 1999,341 (10) :709.
  • 5Pitt B , Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial in- farction[ J]. N Engl J Med ,2003,348 : 1309.
  • 6Mookadam F, Moustafa S E. Prevention of Late Postmyocardial Infarction Left Ventricular Remodeling:An Update[ J]. Curr Heart Fail Rep,2009, 6(4) :245.
  • 7无.急性ST段抬高型心肌梗死诊断和治疗指南[J].中华心血管病杂志,2010,38(8):675-690. 被引量:1968
  • 8吴春涛,王中华,李竹琴,王岚峰.醛固酮受体拮抗剂对心肌梗死后心脏重构影响[J].中华急诊医学杂志,2012,21(2):146-150. 被引量:15

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部