帕罗西汀对门诊抑郁症患者生命质量的影响

The quality of life in depressed outpatients：6-month follow-up study

目的 研究门诊抑郁症患者的生命质量（QOL）及其抗抑郁治疗后生命质量的疗效。方法 多中心合作研究，180例符合抑郁症诊断标准患者，给予帕罗西汀治疗6月，采用HAMD-17、HAMA和SF-36分别在治疗前、治疗3月和6月评价。结果 1）门诊抑郁症患者的生命质量较低（QOL评分〈50分），尤其〈30岁者；2）合并焦虑症状抑郁症组患者的QOL总分[（41．04±12．95）分]明显低于单纯抑郁症组[（48．36±15．76）分]，特别在生理功能（PF）、活力（VT）、社会功能（sF）和精神健康（MH）等方面2组差异有显著性（P〈0．05）；3）抗抑郁治疗后QOL评分显著提高，6月后〉70分（P=0．00），以〈30岁者和合并焦虑症状者改善更为明显。结论 抑郁症患者生命质量有明显降低，抗抑郁药物治疗能显著提高其QOL水平和缓解抑郁和焦虑症状。

Objective To compare the quality of life（ QOL） in depressed outpatients with anti -depressant before and after treatment. Methods It is a multi-center collaborative clinical trial and 180 cases who met the diagnostic criteria of major depression are involved. The patients are treated with paroxetine for 6 months and assessed with HAMD, HAMA and SF-36 at baseline, 3-month and 6-month after treatment. Results 1 ） Before treatment, the QOL scores of all depressed cases are below of 50, particularly among the young cases （aged less 30 years）. 2） The depressed patients who comorbided anxiety symptoms have lower scores of QOL than the depressed cases who have no obvious anxiety symptoms, especially in physical function, virility, social function and mental health （ P 〈 0.05）. 3） After treatment, the QOL score among all cases increase significantly and is over 70 score （ P= 0.00）, especially among young group and comorbided anxiety group. Conclusion The depressed patients have an obvious low level of QOL, but they are able to be improved significantly while they are treated with paroxetine for 6 months.