摘要
近年来研究发现,神经酰胺的积聚与代谢综合征(胰岛素抵抗、高血压、动脉粥样硬化等)有着密切的关系。神经酰胺在外周组织积聚与胰岛素抵抗的发生及程度存在明显相关性,其可抑制胰岛素信号转导与活化,参与游离脂肪酸、肿瘤坏死因子(TNF)-α介导的胰岛素抵抗。神经酰胺及其代谢产物可能参与动脉壁特定细胞的凋亡,介导低密度脂蛋白(LDL)与动脉平滑肌细胞的相互作用;调节血小板激活和凝聚等,与动脉粥样硬化关系密切。另外,神经酰胺及其代谢物还可调节血管紧张度,两种机制提示其可能参与高血压的形成。
In the past few years, studies have shown intimate association between accumulation of ceramide and metabolic syndrome (insulin resistance, hypertension and artheroselerosis). The accumulation of ceramide in peripheral tissue obviously associates with insulin resistance. Ceramide inhibits insulin signaling and action, plays a role in free fatty acid(FFA) and tumor necrosis faetor(TNF)-α-indueed insulin resistance. Roles have been proposed for eeramide or its metabolites in steps of athemgenesis. Ceramide can induce apoptosis of certain cells lining the vessel wall, stimulate the proliferation of endothelial and smooth muscle cells in vessel walls, mediate an inflammatory response, and modulate platelet activation and aggregation. Ceramide or its rnetabolites play important roles in regulating vascular tone, and two mechanisms show eeramide might induce hypertension.
出处
《国际内分泌代谢杂志》
2007年第1期16-18,共3页
International Journal of Endocrinology and Metabolism