摘要
研究发现，与肥胖相关的体重指数、腰臀比的增高，胰岛素抵抗，胰岛素样生长因子-Ⅰ、胰岛素样生长因子结合蛋白-1及性激素结合球蛋白水平的改变，瘦素水平升高及其受体基因变异等与绝经后乳腺癌、上消化道癌、大肠癌、妇科肿瘤、恶性淋巴瘤等发生、发展明显相关。其发病机制可能因肥胖导致高胆固醇和高胰岛素血症，致使体内免疫细胞的活性受到抑制和功能下降。改变不合理的饮食结构和生活行为，加强锻炼保持正常体重可以预防和控制一些相关癌症的发生和发展。
Recent researches have shown that obesity associated factors, such as the body mass index, waist hip ratio, insulin resistance, insulln-like growth-factor-Ⅰ, insulln-like growth-factor binding protein-1, estradiol, sex hormone-binding globulin, leptin and leptin receptor gene overexpression are related to an increased risk of cancers such as breast cancer （postmenopausal）, colorectum, endometrium, gallbladder, esophagus, gastric cardia, Non-Hodgkin lymphoma and renal cell carcinoma. Obesity might change the hormone production and gene overexpression, then affect the proliferation and apoptosis of cells, result in high serum cholesterol and insulin, and the activity and function of the immunocyte was restrain . Controlling the intake of food, changing the dietary habit and lifestyle and enhancing physical activity may prevent the develolpment of some cancers.
出处
《国际内分泌代谢杂志》
2007年第1期59-61,共3页
International Journal of Endocrinology and Metabolism
