肝移植后骨质疏松症的研究进展

Recent progress in osteoporosis after liver transplantation

肝移植后骨质疏松症及其直接导致的骨质疏松性骨折严重影响了移植患者的生存质量。多数终末期肝病患者由于钙、磷代谢紊乱，性腺功能减退，继发性甲状旁腺功能亢进及细胞因子的作用，在移植前就存在骨量减少；而移植后的快速骨量丢失主要与糖皮质激素的应用、遗传因素及手术相关因素有关。密切随访、及时有效的药物治疗对于防治肝移植后骨质疏松症具有积极意义。

Osteoporosis and fracture after liver transplantation have a serious effect on the quality of life. Most patients with advanced liver diseases suffer low bone mineral density because of disturbance of calcium and phosphorous metabolism, hypogonadism, secondary hyperparathyroidism and cytokines. Fast bone loss after transplantation has relation to the administration of glucocorticoid, genetic factors and surgery-related factors. Follow-up timely and treatment efficientiy are important to prevent osteoporosis after liver transplantation.