雌激素对毛囊作用的研究进展

Research progress of estrogen functions in the hair follicle

毛发疾病中仅少部分患者是由于毛干生长紊乱引起，绝大多数还是因为毛发周期变更导致的。雌激素可调节毛发生长，在多数生物中抑制其生长。目前对毛囊中雌激素靶细胞和准确信号通路了解甚少。雌激素还和一些酶及细胞因子间存在复杂的相互作用，形成一个网络，发挥生物学效应。

While only the minority of patients with hair growth disorders have a disturbed hair shaft production, more often the hair loss is due to alterations in hair follicle cycling. Estrogen can modulate hair growth, acting as hair growth inhibitors in most species. Our knowledge about the estrogen target cells and exact signaling pathways in the hair follicle is still very limited. Estrogen also interacts with other enzymes and growth factors, which exerts significant biological effects.