使用不同氟制剂后菌斑氟浓度的动态变化

Study on changes of plaque fluoride concentrations of fluoride products

目的通过测定志愿者使用不同氟制剂后菌斑氟浓度,观察FluorProtector,Bilfluoride,0.2%NaF漱口水,1.23%APF泡沫四种氟制剂使用后,氟在口腔菌斑中的动态变化,了解不同剂型的氟制剂在口腔中的释放情况,为临床选择有效的氟制剂提供实验依据。方法选择56名志愿者,用离子选择性氟电极测定使用四种氟制剂后1、3、7天菌斑氟浓度,并与基线水平相比较。结果无论是使用哪种类型的氟制剂,菌斑氟浓度都显著提高,0.2%NaF漱口水,1.23%APF泡沫只在第一天时高于基线,FluorProtector和Bilfluoride在第一天、第三天都高于基线,Bilfluoride在第七天时仍然高于基线。结论作为缓释制剂的双氟漆和氟保护漆延长了氟在菌斑中的停留时间,使氟的清除速度降低,这有利于防龋作用的发挥。

Objective To evaluate the dynamic changes of plaque fluoride concentrations of volunteers after being used with different fluoride agents so as to discuss their effects on plaque fluorides of different fluoride agents, which could further provide substantial experimental basis for clinical choice of more effective fluoride agents. Methods Fifty - six volunteers were selected for the experiment, divided into 4 groups randomly, which were Fluor Protector group, Bilfluoride group,0.2% NaF rinse group and 1.23% APF foam group. Plaque fluoride concentrations after 1, 3 and 7 days were detected by fluoride ion- specific electrode and the results were compared with those of base levels. Results Plaque fluoride concentrations were all raised after using different fluoride agents. The plaque fluoride concentrations of 0.2% NaF rinse and 1.23% APF foam are higher than the base level just on the first day, but those of Fluor Protector and Bilfluoride are higher than the base level both on the first day and third day, and those of Bilfluoride are higher than the base level on the seventh day. Conclusion Bilfluoride and Fluor Protector can extend the period of time of fluoride concentrations in the plaques and decrease the clearing speed of plaque fluorides, which could in turn facilitate their actions of caries prevention.