转化生长因子α及其受体在腺样囊性癌中的表达及相互关系

The expressions and correlativity of transforming growth facfor-α and epidermal growth factor reptor in salivary adenoid cystic carcinoma

目的探讨转化生长因子α(TGF-α)和表皮生长因子受体(EGFR)在涎腺腺样囊性癌(SACC)中的表达及其相互关系。方法应用免疫组化二步法检测41例腺样囊性癌组织和18例正常涎腺组织中TGF-α和EGFR的表达情况。结果腺样囊性癌组织TGF-α和EGFR的阳性率(51.2%,46.3%)高于正常延腺组织(22.2%,16.7%),P<0.05,有显著差异,且二者呈明显相关性。结论TGF-α和EGFR在腺样囊性癌的发生发展中可能发挥重要的作用,二者有协同性。

Objective To study the expressions and correlativity of transforming growth factor - α（TGF - α）and epidermal growth factor receptor （EGFR） in salivary adenoid cystic carcinoma （SACC）. Methods Immunohistochemical method was adopted to investigate the expression of TGF - α EGFR in 41 SACC tissues and 18 normal salivary gland. Results Positive rates of TGF- α EGFR in SACC（51.2% and 46.3% respecively） were higher than that in normal salivary gland （22.2% and 16.7% respectively）. These differences between SACC and normal salivary gland were statistically significant （ P 〈 0.05） and there was the correlation between TGF- α and EGFR in SACC. Conclusion TGF- α and EGFR may play an important role in the occurrence and develooment of SACC.