HGF/SF-c-Met通路在肿瘤进展过程中的作用及其阻断的研究进展

Progress in effects of the HGF/SF-c-Met on progression of tumors and inhibitors of its pathway

HGF/SF-c-Met通路的过度激活在肿瘤转移过程中起着非常重要的作用,现已证实此通路的激活对肿瘤转移有着近乎全过程的促进作用。近年来,通过对HGF/SF-c-Met通路阻断来抑制肿瘤转移已经成为抗肿瘤研究的热点之一。本文综述有关HGF/SF-c-Met通路在肿瘤生长、侵袭和转移中的作用机制及对此通路抑制剂开发的研究进展。

Over-expression of the HGF/SF-c-Met plays an important role in tumor metastasis. It has been demonstrated that activation of its pathway may promote almost every step of tumor metastasis. Recently, blocking its pathway to prevent tumor cell metastasis has become a focus in anti-tumor studies. This review will address the progress in studies on the effects of HGF/SF-c-Met on growth, invasion, and metastasis of tumors and inhibitors of its pathway.