期刊文献+

新型MEMS微针设计及其力学性能 被引量:7

Design and Mechanical Characteristics of Novel MEMS Microneedles
下载PDF
导出
摘要 描述了三种新型MEMS微针的结构设计及制备方法.针对微针的实际使用要求,对微针的固体力学性质及微通道内液体的流动情况进行了理论分析和数值模拟.结果表明,所设计的三种微针的强度可以保证安全地进行皮肤注射,且适于进行药剂的微量传输. Three novel MEMS microneedles are designed and fabricated. Aiming at practical applications, the mechanical characteristics of the microneedles and process of fluid flowing through the microchannels are studied through both theoretical analysis and numerical simulation with the finite element method. The results show that the microneedles designed here are strong enough to guarantee safe injection through skin,and they are suitable for delivering drugs in micro-volumes.
出处 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2007年第1期113-116,共4页 半导体学报(英文版)
基金 微米纳米加工技术国家重点实验室基金(批准号:51485030105JW0801) 教育部新世纪优秀人才支持计划(批准号:NCET-05-0843) 国家自然科学基金(批准号:10477015)资助项目~~
关键词 微电子机械系统 微针 药物传输 有限元 MEMS microneedle drug delivery finite element method
  • 相关文献

参考文献10

  • 1许宝建,金庆辉,赵建龙.基于MEMS微针技术的研究现状与展望[J].微纳电子技术,2005,42(4):150-156. 被引量:12
  • 2马斌,徐永清,甘志银,张鸿海,刘胜.用于药物释放系统的柔性微针研制[J].半导体技术,2005,30(12):19-22. 被引量:3
  • 3Matsuzuka N,Hirai Y,Tabata O.A novel fabrication process of 3-D microstructures by double exposure in standard deep X-ray lithography.Proc IEEE MEMS,Maastricht,2004:680
  • 4Chandrasekaran S,Frazier A B.Characterization of surface micromachined metallic microneedles.J Microelectron Syst,2003,12(3):289
  • 5Henry S,McAllister D V,Allen M G,et al.Microfabricated microneedles:a novel approach to transdermal drug delivery.J Pharm Sci,1998,87(8):922
  • 6刘天军,侯丽雅,章维一,任志俊.细胞注射微针的流动特性研究[J].中国机械工程,2004,15(8):731-734. 被引量:13
  • 7Stoeber B,Liepmann D.Fluid injection through out-of-plane microneedles.1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine & Biology,2000:224
  • 8Janna W S.Design of fluid thermal systems.Boston:PWS-Kent Publishing Company,1993
  • 9Khumpuang S,Maeda R,Sugiyama S.Design and fabrication of a coupled microneedle array and insertion guide array for safe penetration through skin.International Symposium on Micromechatronics and Human Science,2003:233
  • 10Martanto W,Baisch S M,Costner E A,et al.Fluid dynamics in conically tapered microneedles.American Institute of Chemical Engineers Journal,2005,51(6):1599

二级参考文献56

  • 1李智,俞生,都同功,黄冰,陈系古.转基因显微注射的剂量控制与效果分析[J].中国实验动物学杂志,1998,8(2):65-69. 被引量:12
  • 2李勇,江小宁,周兆英,叶雄英.微管道流体的流动特性[J].中国机械工程,1994,5(3):24-25. 被引量:20
  • 3Pfahler J, Harley J, Bau H.Liquid Transport in Micron and Submicron Channels. Sensors and Actuators,1990,A21-23:431-434
  • 4Wang X H, Zhou Z Y, Ye X Y, et al. PZT-Driven Micropump. Proceedings of the International Symposium on Micromechatronics and Human Science, MHS, Nagoya, Japan, 1998
  • 5Gallardo B S, Gupta V K, Eagerton F D, et al. Electrochemical Principles for Active Control of Liquids on Submillimeter Scales. Science, 1999, 283:57-60
  • 6MCALLISTER D V, WANG P M, DAVIS S P. Micro fabricated needles for transdermal delivery of macromolecules and nano particles: Fabrication methods and transport studies[J].PNAS, 2003,100( 24):13755 -13760.
  • 7ELIAS P M. The stratum corneum as an organ of protection old and new concepts [Z]. 1988,18:308.
  • 8ELIAS P M. The Stratum Corneum as an Organ of Protection: Old and New Concepts 1. Curr Probl Dermatol[Z]. 1989,18:10-21.
  • 9SCHMIDT R, GERHARD T. Human Physiology, 2nd Ed [M]. Springer-Verlag, New York, 1989. 501 - 505.
  • 10BRONAUGH R L, MAIBACH H I.Percutaneous Absorption: Drugs- Cosmetics- Mechanisms- Methodology [M]. Marcel Dekker, New York, 1999.

共引文献25

同被引文献56

引证文献7

二级引证文献28

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部