鼻腔滤泡性树突状细胞肉瘤1例报告并文献复习

Follicular Dendritic Cell Sarcoma of Nasal Cavity:One Case Report and Literature Review

目的:探讨鼻腔滤泡性树突状细胞肉瘤的临床和病理特点,提高对其诊治水平。方法:运用组织病理学及免疫组化观察鼻腔滤泡性树突状细胞肉瘤的特征,总结临床特点和治疗情况,并复习文献加以分析。结果:瘤组织常排列呈结节状、漩涡状和席纹状,瘤细胞呈梭形合体状,核椭圆形,染色质点彩状,有小核仁。瘤细胞CD 35、S-100、和CD 68阳性,K i-67的增殖指数为15%,AE 1/AE 3、CD 34、SM、HHF 35、NF、溶菌酶、CD 21、CD 31、F 8、HM B 45、M e lanA均阴性。结论:滤泡性树突状细胞肉瘤是一种少见的低度恶性肿瘤,发生于鼻腔者更为罕见,诊断依赖组织病理学及免疫组化标记。

Objective：To investigate the clinical and pathologic characteristics of follicular dendritic cell sarcoma （FDCS） of nasal cavity and improve the diagnosis and treatment level of the FDCS of nasal cavity. Methods：The histopathology,immunohistochemistry,elinical characteristics and treatment were reported in I case of FDCS of nasal cavity with review of related literature. Results ：Histopathologically,the FDCS was formed by whorls and fascicles of spindle cells. Immunohistochemical studies showed that the spindle tumor cells were strongly and positive for CD35, S100 protein and CD68,the proliferation index of Ki-67 was 15 percent, but were uniformly negative for cytokeratin AE1/AE3,CD34,SM,HHF35,NF,Iysozyme,CD21,CD31,F8,HMB45,MelanA. It was followed up for 9 months without local recurrence after operation and chemotherapy. Conclusions ：The FDCS of nasal cavity is a rare low-grade malignant tumor. And the diagnosis is based on the histopathology and immunohistochemistry（CD35 and CD21 ）. Local surgical excision is the treatment of first choice. The adjuvant hemotherapy can be the second choice. The prognosis of FDCS of nasal cavity is relative better.