摘要
目的观察二甲双胍联合达因-35对青春期多囊卵巢综合征的治疗作用。方法选择60例青少年多囊卵巢综合征患者,年龄15~25岁。随机分为A、B、C三组,A组18例服用二甲双胍;B组15例服用达因-35治疗;C组27例联合服用二甲双胍和达因-35。三组用药时间均为3个月。测定患者血清卵泡刺激素(FSH)、黄体生成素(LH)和睾酮(T),测量腰/臀比值(WHR)及体重指数(BMI)并进行治疗前后的比较。结果A、C两组治疗后LH、LH/FSH、T及WHR均较治疗前明显降低(P<0.05或P<0.01)且两组间差异无显著性(P>0.05);B组治疗后LH、LH/FSH、T较前明显降低(P<0.01)但WHR明显升高(P<0.05)。A、B、C 3组治疗后各项指标比较:LH、LH/FSH及T差异无显著性(P>0.05),而B组WHR明显高于A、C两组(P<0.05)。结论二甲双胍联合达因-35可以有效治疗青春期多囊卵巢综合征。
Objective To investigate the therapeutic effects of combination of metformin with Diane -35 on cases with adolescent polycystic ovarian syndrome (PCOS). Methods sixty patients with PCOS, aged 15 -25 years, were randomly divided into 3 groups: metformin group (A = 18), Diane-35 group (B = 15), Diane-35 + metform in group( C =27). After a baseline work including serum follicle stimulating hormone (FSH), luterinzing hormone (LH), testosterone (T), waist/hipratio (WHR) and body mass inder (BMI), at the end of 3 months of treatment, all subjects were re -evalua- ted. Results The level of LH, LH/FSH,T and WHR decreased significantly in group A and C after treatment ( P〈0. 05 or P〈0. 01), but there was no significant difference between the two groups (P〉0. 05). In group B, significant decrease of LH, LH/FSH and T were observed compared with pretreatment ( P 〈0. 01 ), while WHR increased markedly ( P 〈0. 05). There were no significant changes of LH, LH/FSH and T among these three groups( P〉0. 05), but the WHR of group B increased significantly compared with the other two groups( P 〈0.05). Conclusions Diane -35 combined with metformin is an effective therapy in dealing with adolescent patients with polycystic ovarian syndrome.
出处
《医学信息(手术学分册)》
2006年第5期63-65,共3页
Medical Information Operations Sciences Fascicule
关键词
青春期
多囊卵巢综合征
治疗
adolescence
polycystic ovarian syndrome
therapy