坎地沙坦酯治疗1—2级原发性高血压疗效观察

Curative effect of candesartan cilexetil in 1 - 2 grade essential hypertension

目的观察坎地沙坦酯片治疗l、2级原发性高血压的临床疗效及其安全性。方法将47例1-2级高血压病人随机分为坎地沙坦酯治疗组（23例）和依那普利对照组（24例），分别给予坎地沙坦4—16mg和依那普利5—20mg，每日1次。每两周测血压一次，如舒张压仍t〉90mmHg，则剂量加倍。进行8周的临床观察。结果两组病人血压均有明显下降（P〈0．01），坎地沙坦酯组的总有效率为82．6％，依那普利组的总有效率为87．5％，两组间未见明显差异（P〉0．05），而坎地沙坦酯治疗组的不良反应较依那普利组要显著减少（P〈0．05）。结论坎地沙坦酯治疗原发性高血压疗效显著，不良反应少，安全有效。

Aim To investigate the clinical efficacy and security of candesartan cilexetil tablets in treatment of 1 - 2 grade essential hypertension. Method 47 patients with 1 - 2 grade essential hypertension were randomly divided into the candesartan cilexetil treatment group （23 cases）and the enalapril control group （24 cases）. They were respectively given candesartan cilexetil tablets 4 - 16 mg and enalapril maleate tablets 5 - 20 mg once a day, the blood pressure measured every two weeks. If the patients＇ diastolic blood pressure 90mmHg,the dose would be doubled. Clinical observation had been carried out for 8 weeks. Result The blood pressures of two groups of patients were both obviously descended（ P 〈0.01 ）. The total effective rate in candesartan group was 82.6% and that in enalapril group was 87.5%. There was no significant difference between the two groups （P 〉 0.05 ）. The adverse effect in candesartan group obviously decreased（ P 〈 0.05 ）. Conclusion Candesartan has obviously curative effect on essential hypertension with less adverse effect.