非职业暴露人群血清有机氯农药残留物暴露水平的横断面研究

Cross-section Study on Serum Organochlorine Pesticides and Residues Level of Non-occupational Exposure Population

目的了解我国非职业暴露人群有机氯农药及其残留物的体内暴露水平、相关因素和性别差异。方法于2004年3—7月,运用横断面研究方法,调查了在成都市某综合性医院体检的107名男性和142名女性,均为社区健康人群。运用气相色谱-电子捕获的方法检测其血清中有机氯农药(DDTs和HCHs)水平。运用线性回归分析有机氯农药与年龄和身高体重指数的关系。结果血清中高检出率的有机氯农药及其代谢产物有p,p’-DDE(≥94.4%)、p,p’-DDT(≥91.6%)、β-HCH(≥82.2%)。女性的血清中上述3种物质水平高于男性(经Mann-Whitney检验,P<0.05)。随着年龄增长,这些物质的蓄积量增加(男性:标准偏回归系数≥0.214,P<0.05;女性:标准偏回归系数≥0.321,P<0.05),增长趋势在女性中更为突出。结论有机氯农药及其残留物在本次调查的非职业暴露人群中有一定蓄积,应重点关注有机氯农药蓄积对女性远期健康的影响。

Objective To understand the body burden and the distribution characters of organochlorine pesticides and residues in non-occupational exposure population. Methods A cress-section study was conducted from Mar. 2004 to Jul. 2004, 107 men and 142 women, who were all healthy community residents, were investigated. Serum DDTs and HCHs level were determined by EC-ECD. The relationship between arganochlorine pesticides in serum and age and BMI were analyzed by liner regression. Results Organochlorine pesticides and residues in serum with high detection rate were β-HCH（≥82.2%）, p,p＇-DDE（≥ 94.4%）, p,p＇-DDT （≥91.6%）, and the level of the three organochlorine pesticides in the serum of women was significantly higher than that in men （Mann-Whitney Test, P〈0.05 ）. Organochlorine pesticides accumulation was related to the age （men：beta ≥ 0.214, P〈0.05; women： betas ≥0.321, P〈0.05）, and this trend was more obvious in women than in men. Conclusion Women are the risk population, more attention should be paid on their long-term health effects caused by exposure of organochlorine pesticides.