脑损伤后情绪障碍的药物康复

Drug Rehabilitation of Emotion Disorders after Brain Injury

脑损伤后的激动,攻击行为与抑郁等现象常见,重者伤人与自伤,且常影响康复及其功效,阻碍病情恢复。夲文对激动病人的处理介绍了抗精神病性药物,情绪稳定剂,即抗癫痫药物的应用与抗焦虑性药物的应用。在对抑郁状态,介绍了三环与四环抗抑郁制剂和选择性5-羟色胺抑制剂(SSRIs)的正规化使用和注意事项。特别提出要注意SSRIs综合征与SSRIs撒药综合征。与使用以上药物特别是吩噻嗪类和丁酰苯类等引发的抗精神病药物恶性综合征,后者如处理不当,死亡率可达25%。

Agitation, aggression and depression are frequent neurobehavioral sequalae after injury of brain. These behavioural symptoms disrupted patient care and impede rehabilitation effort. In ,severe eases, the patient even hurts others and sometime injuries himself. This article introduces the use of antipsychoties, mood stablizing, lithium, antianxiety medication and antidepressants especially the SSRIs for the emotion disturbance after injury of brain. Meantime, paper describes the 5-HT syndrome, withdrawal 5 HT syndrome, the neuroleptic malignant syndrome （NMS）. The later is owing to wrong use of phenothiazines and butyrophenones. The mortality of NMS is about 25%, if case treats is not correct.