血小板源性生长因子与组织修复

Platelet-derived Growth Factors and Tissue Repair

血小板源性生长因子（PDGFs）属糖蛋白二聚体（分子量27000～35000）家族，它向间质源细胞施以有力的促有丝分裂和趋化活性活动。PDGFs在胚胎发育、细胞分化和对组织损伤的反应等过程中具有许多极为重要的作用。它是创面愈合过程中较早出现的生长因子之一。特别是对一些慢性难愈性伤口，如糖尿病溃疡，慢性静脉性溃疡、压疮、放射性溃疡等PDGFs均有明显促进愈合作用。

Platelet-derived growth factors （PDGFs） are a member of family of glycoprotein dimers （Mr 27000-35000） that ex ert potent mitogenic and chemotaetie activities toward cells of mesenchymal origin. The PDGFs possess a myriad of critical roles in embryonic development, cellular differentiation and response to tissue damage. It is one of the growth factors, which appear early during the process of wound healing. Especially,PDGFs can effectively promote the healing of some chronic refractory wounds,such as diabetes mellitus ulcer, chronic venous ulcer, bedsore, radioactivity ulcer, etc..