摘要
在心室收缩过程中，心肌细胞同步收缩产生的力量可以将血液泵出心脏。相反地，在舒张期，心肌细胞松弛和心室的被动性（主要依赖于细胞外基质的特性）决定了两次心跳之间心脏的充盈。体内存在一些相互作用的调节过程来保证心脏的功能可以被精细地调控，以与循环的需要相匹配。本文对调节心脏收缩性的机制作一概述，该机制失调提示机体处于疾病状态，如心力衰竭。
The synchronous contraction of cardiac myocytes during ventricular systole generates the power required to pump blood out of the heart. Conversely, myocyte relaxation and the passive properties of the ventricles during diastole （dependent largely on the properties of the extracellular matrix） determine the filling of the heart between beats. Several interacting regulatory processes operate to ensure that cardiac performance is finely tuned to match circulatory requirements. This contribution provides an overview of the mechanisms that regulate cardiac contractility, dysfunction of which is implicated in disease states such as heart failure.
