异丙酚在无抽搐电休克治疗中镇静的效果评价

Evaluation on the sedative effect of propofol on psychotic patients undergoing modified electroconvulsive treatment

目的:观察异丙酚用于精神病患者无抽搐电休克治疗术(ModifiedElectroconvulsiveTreatment,MECT)的镇静效果及安全性。方法:210例拟行MECT的精神病患者,每例治疗8￣15次不等,观察并记录治疗中患者HR、MAP和呼吸情况以及复苏情况。结果:静脉注射异丙酚后HR无明显变化,MAP显著下降(P<0.01)。与麻醉前相比,电刺激时和电刺激毕MAP、HR均明显升高(P<0.05),电刺激毕HR明显减慢(P<0.05);自主呼吸恢复时间为(3.3±1.8)min,意识恢复时间为(5.1±2.5)min。结论:异丙酚用于无抽搐电休克治疗的镇静安全有效,苏醒迅速,无明显不良反应。

Objective：To evaluate the sedative effect and security of propofol on psychotics undergoing modified electroconvulsive treatment （MECT）.Methods：Tow hundred and ten psychotics undergoing MECT were treated with propofol for sedation and the treating times for each case were diversely 8 to 15.The changes of HR,MAP,SpO2 were monitored,and respiration and recovery time were observed after propofol was administered.Results：Compared with pre-anesthesia,HR remained the same and MAP significantly decreased after propofol was injected intravenously（P〈0.01）;both HR and MAP levels increased at the beginning and end of electro-stimulus （P〈0.05）.HR slowed down at the end of it （P 〈 0.05）.The recovery time of breath was （3.3±1.8）min and the recovery time of consciousness was（5.1±2.5）min.Conclusion：Propofol could be safely and effectively used in MECT for sedation,making the patient get consciousness soon without significant adverse effects.