我院2003～2005年医院获得性鲍曼氏不动杆菌分布与耐药性变迁分析

Distribution and resistant profile analyses of acquired infections of acinetobacter baumanii in our hospital,2003～2005

目的:了解医院内获得性鲍曼氏不动杆菌分布与耐药性变迁。方法:对我院2003￣2005三年间医院内获得性鲍曼氏不动杆菌分布与耐药谱变化进行回顾性分析。用K-B法进行药敏实验,按NCCLS标准判断细菌耐药性。结果:静脉导管、痰、分泌物及胆汁中鲍曼氏不动杆菌检出率较高,达到11.5%￣37.5%。呼吸科、烧伤科、神经外科、心内科、移植科、胸外科、ICU院内感染菌以鲍曼氏不动杆菌为主。鲍曼氏不动杆菌对常用抗生素耐药性逐年增加,对头孢哌酮、氨苄西林、头孢曲松、头孢呋肟、阿莫西林/克拉维酸耐药率均超过50%,左氧氟沙星、美罗培南、亚胺培南、头孢哌酮/舒巴坦、氨苄西林/舒巴坦、哌拉西林/三唑巴坦比较敏感。结论:医院内获得性鲍曼氏不动杆菌感染率逐年增加,对多种抗生素的耐药性高且耐药率增加较快,临床应加强监测,合理使用抗生素,以提高疗效和减缓耐药株的产生。

Objective：To analyses distribution and resistant profile of acquired infections of acinetobacter baumanii.Methods： Distribution and the resistant patterns of acquired infections of acinetobacter baumanii in our hospital were analysed by a retrospective analysis from the year 2003～2005.All of the isolates were tested by Kirby-Bauer susceptibility,and the antibiotic resistance was judged according to NCCLS standard.Results：The isolation rate of Acinetohacter baumannii was the higher in vena pips,sputum,secretion and bile,the isolation rate was 11.5%～37.5% respsctively.Primary acquired infections were Acinetobacter baumannii in department of breathe,burn,neunrosurgery,heart internal medicine,transplantation,chest surgery and intensive care units.The bacterial rcsis-tancet rate to common antimicrobial agents increased year by year.There sistance rate s of Acinetobacter haumonnii to antibiotics such as Cefop-erazone,Ampicillin,Ceftriaxone,Cefuroxime, were over 50% every year rospectively.Levofloxacin,Meraopenem,Imipenem,Cefopera-zone/Sulbactam,Ampicillin/Sulbactam Acid and Piperacillin/Tazabactam all had antisepsis activity to Acinetobacter baumannii relatively.Conclusion：The infection rate and the antibiotics rate of hospital acquired infections of Acinetobacter baumannii was yearly increase,resistance to anti-microbial agents have the characteristics of high prevalence.Its necessary to strengthen the clinic monitoring and select reasonable antibiotic in order to improve curative effect and delay bacteria of resistance to antimicrobial agents.