整合素与胰腺癌

Roles of integrins in pancreatic adenocarcinoma

整合素为一类跨膜蛋白,是介导细胞与细胞外基质黏附的主要黏附分子.他将细胞外的信号传入细胞内调节细胞生长、改变细胞形态、影响细胞运动,并在肿瘤侵袭和转移的过程中起重要作用.胰腺癌手术切除率低死亡率高的重要原因之一是肿瘤早期即能发生局部浸润和远处器官转移,整合素作为细胞与细胞外基质的黏附分子,在胰腺癌侵袭及转移过程中发挥多重作用.

Integrins, serving as transmembrane proteins, play major roles in ceU-extracellular matrix adhesions, and they can introduce extraceUular signals into the cells, alter cellular morphology and influence cell motility as well as contribute to tumor invasion and metastasis. One of the major causes of low resection rates and extremely poor survival rates is its extraordinary local tumor progression and early systemic dissemination. Being a kind of adhesion molecules associating cells with extraceUular matrix, integrins play a variety of roles in the process of invasion and metastasis in pancreatic adenocarcinoma.