抗生素药品干燥失重与费休氏水分测定方法比较

Comparison between the Loss on Drying Method and the Karl Fisher Reaction Method for Determining Antibiotic Drugs

目的:通过比较试验考察两种水分测定方法有无显著性差异。方法:应用常压干燥失重法及费休氏法进行水分测定。结果:通过试验比较,干燥失重水分测定法与费休氏水分测定法无显著性差异。结论:部分药品的水分测定可用干燥失重法代替药典规定的费休氏法。

Objective： To determine whether the two moisture measuring methods bold significant difference by comparative test. Method： To apply the loss on drying method under normal pressure and the Karl fischer reation method both. Result： According to comparison, the two testing methods bold no significant difference in result. Conclusion： For some of the drugs, we can apply the loss on drying method under normal pressure instead of the Karl fischer reaction method for moisture content testing.