期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

5,8-二取代喹唑啉类化合物LJK-11对HER2高表达肿瘤细胞的作用和分子机制初探 被引量：2

Effects and molecular mechanism of 5,8-disubstituted quinazolines-LJK-11 in HER2 overexpressing cells
下载PDF
导出
摘要 目的观察LJK-11对HER2高表达细胞的作用。方法检测LJK-11对不同肿瘤细胞作用的剂量效应;用Western blot检测药物引起的细胞内酪氨酸激酶信号表达变化。结果随着药物浓度的增加,LJK-11对肿瘤细胞的增殖抑制作用逐渐明显,并能够引起肿瘤细胞的凋亡;Western blot检测显示受体酪氨酸激酶HER2磷酸化表达降低。结论LJK-11可能是一种新型的酪氨酸激酶抑制剂,这一作用机制将为研制出新型的抗肿瘤药提供理论依据。 Objective To investigate the effects and molecular mechanism of LJK-11 on tumor cell. Methods The growth inhibition effects of LJK-11 on different tumor cell were measured by MTT assay. The effects on the expression and phosphorylation of HER2 were analyzed by western blot analysis. Results LJK-11 inhibited tumor cell growth in concentration-dependent manner. LJK-11 inhibited the phosphorylation of HER2.Conclusions LJK-11 may be developed as a novel kinase inhibitor. The inhibitory mechanism of LJK-11 provides a theoretical guidance for the development of novel anti-cancer agents.
作者 秦莉莉 金毅 龙亚秋 俞强 何建勇
机构地区 沈阳药科大学制药工程学院 中国科学院上海药物所
出处 《沈阳药科大学学报》 CAS CSCD 北大核心 2007年第1期53-56,60,共5页 Journal of Shenyang Pharmaceutical University
关键词 LJK-11 酪氨酸激酶抑制剂 肿瘤 HER2 细胞死亡 LJK-11 tyrosine kinase inhibitor tumor HER2 cell death
分类号 R966 [医药卫生—药理学]
  • 相关文献

参考文献12

  • 1MENDLSOHN J,BASELGA J.The EGF receptor family as targets for cancer therapy[J].Oncogene,2000,19:6550-6565.
  • 2DEBONO J S,ROWINSKY E K.The ErbB receptor family:a therapeutic target for cancer[J].Trends Mol Med,2002,8:(4 Suppl) 19-26.
  • 3OLAYIOYE M A,NEVER M,LANE H A,et al.The ErbB signaling network:receptor hetero dimerization in development and cancer[J].EMBO,2000,19(13):3159-3167.
  • 4SALOMON D S,BRNDT R,CIARDIELLO F,et al.Epidermal growth factor-related peptides and their receptors in human malignancics[J].Crit Rev Oncol Hematol,1995,19(3):183-232.
  • 5ARTEAGA C L.Epidermal growth factor receptor dependence in human tumors:more than just expression[J].Oncologist,2002,7:31-39.
  • 6SAINSBUR Y R,FARNDON J R,NEEDHAM G K,et al.Epidermal-growth-factor receptor status as predictor of early recurrence of and death from breast cancer[J].Lancet,1987:1398-1402.
  • 7BRABENDER J,DANENBERG K D,METZGER R,et al.Epidermal growth factor receptors and HER2-neu mRNA expression in non-small cell lung cancer is correlated with survival[J].Clin Cancer Res,2001,7:1850-1855.
  • 8VEALE D,KERR N,GUBSON G J,et al.The relationship of quantitative epidermal growth factor receptor expression in non-small cell lung cancer to long term survival[J].Br J Cancer,1993,68(1):162-165.
  • 9NAKAMURA H,TAKAMORI S,FUJII T,et al.Cooperative cell-growth inhibition by combination treatment with ZD1839 (Iressa) and trastuzumab (Herceptin) in non-small-cell lung cancer[J].Cancer Lett,2005,230 (1):33-46.
  • 10YANG G,CAI KQ,THOMPSON-LANZA J A,et al.Inhibition of breast and ovarian tumor growth through multiple signaling pathways by using retrovirus-mediated small interfering RNA agaiinst Her-2/neu gene expression[J].Biol Chem,2004,279(6):4339-4345.

同被引文献39

引证文献2

二级引证文献12

沈阳药科大学学报
2007年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部