N-甲基吗啉绿色合成研究

Green Synthesis of N-Methylmorpholine

N-甲基吗啉生产的传统工艺条件苛刻,对设备腐蚀严重、对人体造成巨大危害、对环境造成严重污染。利用碳酸二甲酯和吗啉为原料合成了N-甲基吗啉,采用正交试验方法讨论了原料配比、反应时间、反应温度对收率的影响,并得出了优选反应工艺条件为:物料配比为n(C4H8NO)∶n(C3H6O3)=1∶1.2,反应时间为3 h,反应温度为100℃。在此条件下的产品经色质联用仪检测,产品收率可以达到95%以上。结果表明:此法具有原料价廉易得、操作容易控制、不污染环境,是一条简单易行的典型的绿色合成途径。

The conditions for synthesizing N - Methylmorpholine by traditional method were very hard and this method would do harm to equipment, human body and environment. N - Methylmorpboline was synthesized by reaction of morpholine with methyl carbonate. The effects of molar ratio of reactants, reaction time and reaction temperature on the yield were investigated by orthogonal experiments. The optimum conditions for reaction were as follows： n （morpholine） ： n （ methyl carbonate） = 1： 1.2, reaction time was 3 h and reaction temperature was 100℃. And the yield of N - Methylmorpholine reached 95% tested by GC - MS, The results showed that this method had many advantages such as simple operation, environment friendly, and the raw materials were cheap and easy to obtain. It was a green method for synthesizing N - Methylmorpholine which was simple and typical.