参附联合丹参注射液治疗老年多器官功能不全综合征机制探讨

The Probeon the Mechanism of Shenfu Injection(参附注射液) Combined with Danshen Injection(丹参注射液) Treating Multiple Organ Dysfunction Syndrome in Elder

老年多器合功能不全综合征(MODSE)中医病机特点为阳虚血瘀、络脉阻滞;阳气亏虚、脏腑衰弱为其发病的内在基础;阳虚血瘀、络脉阻滞为其病机关键。温阳益气、活血化瘀是治疗MODSE的根本大法。参附联合丹参注射液具有延长动物耐缺氧时间、增加冠脉血流量、抗休克、抗脂质过氧化、调节免疫功能、改善血液流变学、兴奋垂体-肾上腺皮质功能、增强机体非特异性抵抗力、抗菌、抗损伤、抗膈肌疲劳等作用,从而对循环、呼吸、血液、中枢神经以及肾脏、胃肠等多系统、多器官的功能起到改善和保护作用;在多方面、多环节对MODSE发挥治疗作用,并在缩短MODSE病程及预防其发展为多脏衰等方面也具有重要的意义。

The characteres of pathogenesis are Insufficiency of Yang and Blood Stasis, and Blocker of Collateral Branch of the Larger Channel. Especial, Insufficiency of Yang and Visceral Dysfunction are intrinsic, the pathological center is Blood Stasis of Insufficiency of Yang and Blocker of Collateral Branch of the Larger Channel. The basic principle of MODSE is Warming Yang for Qi and Promoting Blood Circulation to Remove Blood Stasis. Shenfu Injection（参附注射液） combined with Danshen Injection（丹参注射液） can prolong the aerotolerant time, increase the flow volume of coronary, antishock, against the lipid peroxidation, improve the function of immunity, ameliorate hemedynamics, excite function of pituitary-cortex of adrenal gland system, enhance the non-special resistance, antisepsis, against the injury and injury of diaphragm, and finally improve and protect the function of circulation, respiration, blood, central nerve, kidney, and gastrointestinal tract. Shenfu Injection combined with Danshen Injection treating MODSE involed in many systems, and shorten course of MODSE and prevent multiple organ failure.