甲氧普胺对琥珀胆碱的时－量关系及阻滞性质的影响

Effect of Metoclopramide on the Time Dose Relationship and Neuromuscular Blockade of Succinylcholine

２０例择期普胸、脊柱手术病人随机分为１组（甲氧普胺组）和２组（对照组）。１组术前３０ｍｉｎ肌注甲氧普胺０．３ｍｇ／ｋｇ，２组未用甲氧普胺。麻醉诱导后用２％普鲁卡因复合０．０８％琥珀胆碱静滴维持麻醉，用加速度仪监测神经肌肉阻滞及阻滞性质，同时采血测定血浆胆碱酯酶活性。结果：１组肌注甲氧普胺后血浆胆碱酯酶活性下降３４．８％，与２组同时值比较有显著差异。维持肌颤搐Ｔ１１０～２０％两组琥珀胆碱用量及停药后肌张力恢复时间无明显差异，１组１０例均出现双相阻滞。结果表明，术前常规剂量甲氧普胺对琥珀胆碱的时－量关系无明显影响，但影响其阻滞性质。

20 patients scheduled for spinal or thoracic surgery were randomly divided into metoclopramide(group 1) and control group (group 2).30 minutes before induction of anesthesia, metoclopramide 0 3mg/kg im to patients of group 1 was given. Both groups of patients were intraveneously infused procaine mixed with succinycholine following induction. The neuramuscular block was determined by means of TOF. Blood samples were taken to measure serum cholinesterase. The results indicate that serum cholinesterase activity was inhibited significantly by metoclopramide and the characteristic of neuromuscular blockade of Sch was altered. But the time dose relationship of Sch was not changed.