富马酸二甲酯的固体酸催化合成及HPLC检测

DMF Synthesize by Solid Superacid Catalyst and Determination by HPLC

以SO4^2-／TiO2固体超强酸为催化剂催化富马酸与甲醇合成富马酸二甲酯，探讨了催化剂制备条件、原料配比、反应时间、催化剂用量等因素对富马酸二甲酯收率的影响。并采用HPLC，快速方便地检测富马酸二甲酯的收率，并考察由不同比例的甲醇／水、乙腈／水组成的流动相对分离的影响。试验证明，在最优条件下，富马酸二甲酯的产率可达到78．6％。

Synthesis of dimethyl fumarate（DMF） by esterification of fumaric acid with methanol catalyzed by solid superacid SO4^2-/TiO2 was proposed in this paper. The influences of catalyst preparation, reaction time and amount of catalyst used on the yield of DMF were investigated. Also it described a rapid and simple determination method for DMF and it＇s relative contents by HPLC. The effect of composition and type of the mobile phase on separation was examined. The yield of DMF can reach 78.6% under the optimal reaction conditions.