摘要
A flow injection chemiluminescence method for the determination of Cefepime hydrochloride is descrbed.The method is based on the chemiluminesence emitted during the oxidation of Cefepime hydrochloride by N-bromosuccinimide（NBS）in alkaline medium in the presence of fluorescein as energy transfer.The chemiluminescence intensity is proportional to cefepime hydrochloride concentration over the range 0.05mg·L-110mg·L-1.The detection limit is 29μg.L-1and the relative standard deviation is 4.3% for 5mg·L-1cefepime hydrochloride（n=11）.This method had been successfully applied to determination of cefepime hydrochloride in injections.
A flow injection chemiluminescence method for the determination of Cefepime hydrochloride is descrbed. The method is based on the chemiluminesence emitted during the oxidation of Cefepime hydrochloride by N- bromosuccinimide （NBS）in alkaline medium in the presence of fluorescein as energy transfer. The chemiluminescence intensity is proportional to cefepime hydrochloride concentration over the range 0. 05mg · L^-l ～ 10mg ·L^-l. The detection limit is 29μg. L^-l and the relative standard deviation is 4. 3% for 5mg· L^-lcefepime hydrochloride（n = 11 ）. This method had been successfully applied to determination of cefepime hydrochloride in injections.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2007年第1期118-120,共3页
Chemical Research and Application
基金
重庆市教委科学研究项目(041304)资助
关键词
化学发光
流动注射
盐酸头孢吡肟
N-溴代琥珀酰亚胺
荧光素
Chemiluminescence
flow injection analysis
N - bromosuccinimide
fluorescein
cefepime hydrochloride
