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宫颈癌新鲜组织和石蜡包埋组织中端粒酶检测比较 被引量：1

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摘要 目的为了了解宫颈癌新鲜组织和石蜡包埋宫颈癌组织中端粒酶活性检测的差异。方法TRAP-PCR用于30例宫颈新鲜组织和40例石蜡包埋的宫颈组织中端粒酶活性的检测。结果宫颈癌新鲜组织端粒酶活性检出率为73.33%(22/30),石蜡包埋的宫颈癌组织检出率为27.50%(11/40)(P<0.001)。两组平均端粒酶活性分别为1.362±0.768和0.624±0.386(P<0.001)。结论宫颈癌新鲜组织端粒酶活性检出率显著高于石蜡包埋的宫颈癌组织,平均端粒酶活性有极显著差异。
作者 欧阳耀灵 范翠芳 居文惠 杨勇 陈登峰
机构地区 湖北省荆州市中心医院检验医学部 湖北省荆州市中心医院妇产科 湖北省荆州市中心医院病理科 湖北省荆州市中心医院肿瘤科
出处 《中国优生与遗传杂志》 2007年第1期31-31,4,共2页 Chinese Journal of Birth Health & Heredity
关键词 宫颈癌 端粒酶活性 宫颈癌组织 石蜡包埋
分类号 R737.33 [医药卫生—肿瘤]
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参考文献3

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二级参考文献7

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共引文献8

同被引文献17

  • 1张毓文,王茹英.端粒酶含量测定在宫颈癌发展及预后中的意义[J].实用医技杂志,2007,14(26):3592-3593. 被引量：1
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  • 3FAN Yi-bo, WU Xin, FU Zhi-min, et al. Amplification of the human telomerase gene in liquid - based preparations is associated with cervical dysplasia and carcinoma [ J]. International Journal of Gynecological Pathology : Official Journal of the International Society of Gvnecolo~,ical Pathologists. 2010. 29 ( 2 ) : 157 - 164.
  • 4ANDERSSON S, SOWJANYA P, WANGSA D, et al. Detection of genomic amplification of the human telomerase gene TERC, a potential marker for triage of women with HPV-positive, abnormalPap smears [J]. The American Journal of Pathology, 2009, 175 (5) : 1831 - 1847.
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  • 8HESELMEYER - HADDAD K, SOMMERFELD K, WHITE N M, et al. Genomic amplification of the human telomerase gene ( TERC ) in pap smears predicts the development of cervical cancer [ J]. The American Journal of Pathology, 2005, 166 (4) : 1229 - 1238.
  • 9PARK T W, RIETHDORF S, SCHULZ G, et al. Clonal expansion and HPV - induced immortalization are early molecular alterations in cervical carcinogenesis [J].Anticancer Research, 2003, 23(1A) : 155 -160.
  • 10YANGY-c, SHYONG W Y, CHANG M-s, et al. Frequent gain of copy number on the long arm of chromosome 3 in human cervical ad [ J]. Cancer Genetics and Cytogenetics 2001, 131(1) : 48 -53.

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中国优生与遗传杂志
2007年 第1期

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