IGF-I与子宫内膜异位症相关关系的研究

Relationshipe of the IGF-I and endometriosis.

目的观察胰岛素样生长因子-I(IGF-I)及其受体(IGF-IR)在子宫腺肌症患者原位及异位内膜表达,以探讨子宫腺肌症发生维持及侵袭的机制。方法取20例子宫腺肌症患者的原位和异位内膜标本作为病例组,另取22例正常内膜作为对照组。采用免疫组织化学方法检测IGF-I,IGF-IR的分布及表达。结果正常内膜及子宫腺肌症的原位和异位内膜组织中均有IGF-I,IGF-IR的表达,IGF-I在异位内膜组织中表达较高(P<0.05=。结论IGF-I可能参与子宫腺肌症的异位内膜生长与维持。

Objective： To investigate insulin -like growth factor Ⅰ （ IGF- Ⅰ） and insulin -like growth factor Ⅰ receptor （ IGF- IR） which are distributed and expressed in eutopic and ectopic endometria from adenomyosis patients, by this way, and explore mechanisms of occurrence sustainance and invasion of adenomyosis. Methods： Tissue specimens of eutopic and ectopic endometria were obtained from 20 patients with adenomyosis. 22 specimens of the normal endometrium served as controls. They were tested for the distribution and expression of IGF - Ⅰ and IGF - IR by immunohistochemical analysis. Results ： It was demonstrated that IGF - Ⅰ and IGF - IR were present in normal, ectopic and oeutopic endometrial tissue. For IGF - Ⅰ, the immunostaining score was higher in ectopic endometrial tissue. Conclusion ： IGF - Ⅰ could possibly taken part in mechanisms of development and sustainanec of adenomyosis.