摘要
目的总结原发性肝细胞肝癌(primary hepatocellular carcinomas, PHC)的家族聚集现象和家族性PHC的临床特点。方法回顾性分析了34例家族性PHC的临床表现,并进行了家系调查。结果34例PHC患者分布在8个家系中,平均4.25例(3.9例);患者发病年龄平均41.3岁(32-62岁),肝炎病毒感染率94.1%(32/34),肝炎或肝硬化率61.8%(21/34).AFP阳性率82.4%(28/34),就诊时TNM分期Ⅱ期2例,Ⅲ期23例,Ⅳ期9例;生存时间1-25月,平均7.3月。结论通过家族史明确高危人群、有重点地定期检查,提高治疗效果,为目前切实可行的PHC防治策略和思路。
Objective: To sum up clinical manifestation and familial genetics of primary hepatocellular carcinomas (PHC). Methods : Retrospective analysed 34 patients with PHC and explorited thire familial genetics. Results : All 34 cases of PHC were in 8 families and every family was 4. 25 cases (3-9 eases). The averagy years of PHC patients were 41.3 (32 -62) years old. Thief hepatitis virus rates were 94. 1% (32/34) and hepatitis/eirrosis were 61.8% (21/34). Thief AFP positive rates were 82.4% (28/ 34). TNM stage Ⅱ, Ⅲ,Ⅳ of PHC patients were 2, 23, 9 cases respectively. Allover survival time of them was 7. 3 monthes ( 1 - 25). Conclusion: These results suggest that familial genetics might play an important role in earlier prevention measures and diagnosis as well as more effective therapies of PHCs.
出处
《中国优生与遗传杂志》
2007年第1期110-111,61,共3页
Chinese Journal of Birth Health & Heredity
关键词
原发性肝细胞肝癌
遗传学
临床分析
家系调查
Primary hepatocel lular carcinomas (PHC)
Genetics
Clinical manifestation
Family exploration