老年性黄斑变性的黄斑区密集点矩阵视野

ANINVESTIGATIONOFAGE┐RELATEDMACULARDEGENERATIONBYUS┐INGDENSEMATRIXMAPPINGINMACULA

目的：应用黄斑区密集点矩阵视野（ｄｅｎｓｅｍａｔｒｉｘｍａｐｐｉｎｇｉｎｍａｃｕｌａ，ＤＭＭＭ）探讨老年性黄斑变性（ａｇｅ－ｒｅｌａｔｅｄｍａｃｕｌａｒｄｅｇｅｎｅｒａｔｉｏｎ，ＡＭＤ）视功能变化及评价其在ＡＭＤ早期诊断中的应用价值。方法：用Ｈｕｍｐｈｒｅｙ－６４０视野计自行设计ＤＭＭＭ检测正常对照组１６人２４只眼，ＡＭＤ干性组５１例７１只眼，湿性组２３例２７只眼。结果：①黄斑区２．５°内ＤＭＭＭ各组平均光敏感度阈值（ｍｅａｎｌｉｇｈｔｓｅｎｓｉｔｉｖｉｔｙ，ＭＬＳ）：ＡＭＤ干性组３３．３０±２．４９，湿性组２０．６７±８．３０，正常老年人组３５．６１±１．３７，组间ｔ检验均有高度显著差异。②黄斑区５°内ＭＬＳ：ＡＭＤ干性组３２．９５±１．８２，湿性组２２．１１±７．７４，正常老年人组３４．９３±１．４６，组间ｔ检验，均有高度显著差异。结论：ＡＭＤ干性组早期便有ＤＭＭＭ的ＭＬＳ改变。ＤＭＭＭ评价ＡＭＤ视功能早期改变的敏感性较高。

PURPOSE:Toapproachthechangesofvisualfunctionbyusingthedensematrixmappinginmacula(DMMM)inpatientswithage-relatedmaculardegeneration(AMD).METHODS:TheDMMMwasdesignedusingHumphrey-640,thestudyincluded51patients(71eyes)indrytypeAMD,23patients(27eyes)inwettypeand16normalelderly(24eyes).RESULTS:In2.5degreeofmacula:themeanlightsensitivity(MLS)was35.61±1.37innormalelderly,33.30±2.49indrytypegroupand20.67±8.30inwettypegroup,anddiferenceswerehighlysignificantstatisticalyamongthem.In5degree:theMLSis34.93±1.46innormalelderly,32.95±1.82indrytypegroup,22.11±7.74inwettypegroup,andthediferenceswerehighlysignificantstatisticalya-mongthem.CONCLUSIONS:TheMLSofDMMMdeclinedatearlystageofdrytypeAMDandtherewasrelativelyhighsensitivityofMLSofDMMMinevaluatingthevisualfunctioninearlyAMD.