伤痛宁康合剂的药效学实验研究

Experimental Study on Pharmacodynamics of ShangTongLingKang Mixture

目的研究伤痛宁康合剂的药理作用。方法采用大鼠急性软组织损伤模型和足跖血肿模型以及小鼠急性淤血型微循环障碍模型观察其治疗作用。结果伤痛宁康合剂能明显地减轻损伤局部的炎性反应和促进肌纤维的再生;明显地减轻损伤组织的出血、淤血;促进血肿吸收和淤斑消散;显著地改善微循环障碍表现。结论伤痛宁康合剂具有活血化淤、消肿、抑制损伤组织无菌炎症,促进组织修复和改善淤血型微循环障碍的作用。

Objective To investigate the pharmacological effect of ShangTongLingKang Mixture （STLKM）. Methods The models of acute soft tissue injury, plantar hcmatoma resulted from themselves blood in rats, and acute microcirculation disturbance of blood stasis in mice were used to observe the therapeutic effects of STLKM. Results STLKM could significantly relieve topical intlammatory reaction and promote regeneration of muscle fiber. It also remarkably relieved the bleeding, blood stasis of injured tissue, reinforce the absorption of hematoma and the dissipation of ecchymosis, as well as improve microcirculation disturbance. Conclusion STLKM has remarkable effects of invigorating circulation of blood, dispersing blood stasis,eliminating swelling, inhibiting aseptic inflammation, accelerating repair and improving microcireulation disturbance on injured tissue.