足三里配不同穴改善急性胃黏膜损伤作用的对比研究

Comparative study on different point combinations of Zusanli (ST 36) for improving acute gastric mucosa injury

目的:观察足三里配不同穴改善急性胃黏膜损伤的作用,探讨其机理。方法:100只大鼠随机分为10组,即“足三里”组(A组)、“足三里”配“内关”组(B组)、“足三里”配“中脘”组(C组)、“足三里”配“公孙”组(D组)、“足三里”配“内关”“中脘”组(E组)、“足三里”配“内关”“公孙”组(F组)、“足三里”配“中脘”“公孙”组(G组)、“足三里”配“内关”“中脘”“公孙”组(H组)、模型组(I组)、空白对照组(J组),每组10只。用无水乙醇按0·6mL/100g灌胃,造成胃黏膜损伤模型。检测各组治疗结束后胃黏膜损伤指数(UI)、表皮生长因子(EGF)、一氧化氮(NO)、胃泌素(GAS)含量。结果:各电针组EGF含量明显高于模型组(P<0·01),并能提高NO含量,降低GAS含量,与模型组比较差异有显著性意义(P<0·05);A组、B组、D组之间比较差异无显蓍性意义,而C组、F组、H组与A组比较差异有显著性意义;H组与其他各电针组比较差异有显著性意义。结论:“足三里”不同配穴能改善急性胃黏膜损伤程度,尤以“足三里”配“内关”“中脘”“公孙”组改善急性胃黏膜损伤作用最强。

Objective To compare effects of different point combinations of Zusanli （ST 36） for improving acute gastric mucosa injury and study on the mechanism. Methods One hundred rats were randomly divided into 10 groups, Zusanli （ST 36） group （group A） ; Zusanli and Neiguan （PC 6） group （group B） ; Zusanli and Zhongwan （CV 12） group （group C） ; Zusanli and Gongsun （SP 4） group （group D） ; Zusanli, Neiguan and Zhongwan group （group E）; Zusanli, Neiguan and Gongsun group （group F）; Zusanli, Zhongwan and Gongsun group （group G）; Zusanli and Neiguan, Zhongwan, Gongsun group （group H）; model group （group I）; blank control group （group J）, 10 rats in each group. Gastric mucosa injury model was made by intragastric infusion of dehydrated alcohol （0.6 mL/100 g）. The gastric mucosa injury index （UI）, epidermal growth factor （EGF）, nitric oxide （NO） and gastrin （GAS） contents were detected. Results Contents of EGF and NO were significantly increased and GAS content decreased in all of the EA groups as compared with those in the model group （P〈0. 01 or P〈0.05）, with no significant differences among group A, B and D, and significant differences as group A compared with group C, F and group H compared with other EA groups. Conclusion Different point combinations of Zusanli （ST 36） can improve acute gastric mucosa injury, with the strongest effect in the Zusanli and Neiguan, Zhongwan, Gongsun group.