阿奇霉素对麻花肉鸡的亚急性毒性研究

Studies of subacute toxicity of azithromycin in Mahua broilers

将80只19日龄麻花肉鸡随机分为4组,每组2个重复,分别以0、50、100、200 mg/L阿奇霉素水溶液供试验鸡连续自由饮用14 d,观察其亚急性毒性作用。结果显示,低剂量组(50 mg/L)鸡的生长速度、饲料转化率显著强于其他组(P<0.05);高剂量组(200 mg/L)鸡血清丙氨酸氨基转移酶活性和肝脏器系数与对照组(0 mg/L)和低剂量组存在极显著差异(P<0.01),肝肿大变黄,质脆,出现坏死灶,胆囊肿大,胆汁充盈,肝细胞排列无序、胞浆空泡化、弥漫性脂肪变性。表明,低剂量阿奇霉素能促进鸡生长,大于100 mg/L则对肝、胆产生毒性作用。

To investigate subacute toxicity of azithromycin in Mahua broilers, eighty 19-days-old Mahua broilers were divided randomly into four groups and the 4 groups were given 0,50,100 and 200 mg/L azithromycin by freely drinking for 14 days, respectively. Growth rate and feed conversion rate in 50 mg/L group were significantly higher than that in the other groups（P〈0.05）. The activity of alanine transaminase（ALT） and liver coefficient in 200 mg/L group increased significantly compared with that in control group and 50 mg/L group（P〈0. 01）. Livers of chickens in 200 mg/L group became swollen, yellow and fragile and appeared necrotic focus, and Gallbladder was intumescent and filled with gall. Di sordered distribution,vacuolar plasms and diffuse fatty degeneration were observed in liver cells in the 200 mg/L group. The results showed that growth rate of broilers was promoted by 50 mg/L azithromycin but inhibited by azithromycin over 100 mg/L.