泛素-蛋白酶体系统与心血管疾病

Ubiquitin-proteasome system and cardiovascular diseases

泛素-蛋白酶体系统主要由泛素激活酶(E1)、泛素交联酶(E2)、泛素连接酶(E3)和26S蛋白酶体组成,是降解细胞内蛋白质的主要途径。泛素-蛋白酶体系统参与真核细胞许多生物学功能,如炎症、细胞增生、信号传导、转录调控、细胞凋亡等的调节。近年研究证实泛素-蛋白酶体系统在心血管疾病中具有重要的病理生理学意义,可调节动脉粥样硬化、缺血后再灌注损伤、家族性心肌病、心肌肥厚和心脏衰竭等重要疾病的发生和发展。本文拟就泛素-蛋白酶体系统的结构、功能、调节及在心血管疾病中的作用作一简述。

The ubiquitin-proteasome system （UPS） containing ubiquitin-activating enzyme （El ubuquitin-conjugating enzyme （E2s）, ubiquitin-ligase （E3s） and 26S proteasome, is involved in the degradation of most intracel- lular proteins. One major function of UPS is to prevent accumulation of non-functional and potentially toxic proteins. Moreover, it has become clear that the UPS fulfills an important function in most aspects of eukaryotic biology, such as inflammation, cell proliferation, intracellular signaling , transcriptional control, and apoptosis. Recent studies demonstrated that the UPS regulates the initiation and progression of atherosclerosis, ischemia-reperfusion injury, familial cardiomyopathies, about structure, function, regulati hypertrophic and heart failure. This review briefly summarizes current knowledge on of UPS and its pathophysiological role in cardiovascular diseases.