酿酒酵母促分裂原蛋白激酶Hog1p介导的渗透胁迫反应调控机制

Molecular Mechanism of MAPK Hog1p in Response to Osmotic Stress in Saccharomyces cerevisiae

高渗透性甘油促分裂原激酶信号转导途径(high osmolarity glycerol mitogen activated protein kinase signaling transduction pathway,HOG-MAPK)是调控酿酒酵母对外界高渗透压胁迫环境应答的主要途径,促分裂原蛋白激酶Hog1p(MAPK Hog1p)是其中的关键性作用因子.在高渗透压刺激时,MAPK Hog1p接受信号被特异性激活并进入核内,调控相关胁迫应答基因的表达,并介导该时期细胞周期的阻滞,从而增强细胞对外界不利环境的适应能力.对胁迫条件下酿酒酵母中MAPKHog1p作用机制的进一步研究,有利于更深入地了解哺乳动物体内逆境激发促分裂原蛋白激酶途径的功能和调控机制.

The HOG pathway is the most prominent pathway that allows S. cerevisiae cells to perceive and quickly respond to altered osmolarity, MAPK Hog1p is the key factor in the HOG pathway. Exposure of cell to the high osmotic stimuli leads to the specific activation of MAPK Hog1p and promotes a rapid nuclear concentration. Under stress conditions, Hog1p involved in various regulatory mechanisms, such as the regulation of stress-responsive gene and transient cell cycle arrest, to mediate the adverse environmental adaptability of yeast cells. Further study in MAPK Hog1p mechanisms could improve understanding of the stress-activated mitogen protein kinase signal pathway in mammal.