缺氧预适应研究的进展与展望

Progresses of Prospects for Hypoxic Preconditioning

缺氧预适应这一生物进化上的内源性细胞保护机制,可被机体、器官、组织和细胞的重复缺氧暴露所激发。缺氧预适应的效应已由对重复缺氧局部/原位器官组织的保护(局部/原位缺氧预适应)发展到既保护远隔的各种异位器官组织(远程/异位缺氧预适应)又抗御其它种种非缺氧性应激(交叉/多能缺氧预适应)。在现有进展的基础上,缺氧预适应研究以及其可操作性和可应用性将有更大的发展空间。

Hypoxic preconditioning （HPC）, a strategy of intrinsic cytoprotection developed in biological evolution, is designed to be motivated by repetitive exposure of organism, organ, tissue and cell to condi- tion of hypoxia. The effect of HPC is broadened remotely to protect different organ-tissues in other regions （ remote/ectopic HPC, r/e HPC ） and crossly to resist a variety of stresses other than hypoxia （ cross/ pluripotential HPC, c/pHPC ） from protection of original local in situ organ-tissue repeatedly exposed to hypoxia （ local/in situ HPC, l/Ii HPC）. More spaces for development of feasibility and applicability in the research on HPC would be expected based on the progresses recently available.