血流剪切力在动脉粥样硬化形成中的作用

Roles of Shear Stress in Atherogenesis

血管内皮位于血管壁和血液的界面,直接与血流接触而持续受血流剪切力的作用。血管内皮细胞能感受血流机械力的变化,通过激活相应的信号通路调节血管内皮和平滑肌的结构和功能。研究发现,血液流动力的形式与动脉粥样硬化的发生发展有密切的关系。本综述将就血流剪切力与动脉粥样硬化的相互关系及作用机制的最新研究进展作简要介绍。

Located between circulating blood and vessel wall, vascular endothelial cells （ECs） are constantly exposed to shear stress resulting from blood flow. The mechanical actions of shear stress can be detected by mechanosensors on ECs and converted into specific signaling pathways to mediate the structural and functional remodeling. Patterns of shear stress may contribute to the focal distribution of atherosclerotic lesions. Here, we review recent advances regarding the roles of shear stress in atherogenesis.