胶束增敏荷移分光光度法测定药物奎尼丁

Spectrophotometric Determination of Quinidine by Charge-Transfer Reaction with Micelle-Sensitized

提出了一种基于胶束增敏荷移反应测定奎尼丁的光度分析法．实验发现，阳离子表面活性剂十六烷基三甲基澳化铵（CTAB）胶束体系对电子给体奎尼丁与电子受体氯冉酸之间荷移反应产物具有较强的增敏作用，使络合物的袁观摩尔吸光系数提高了近50％（在λmax=530nm时ε=2．41×10^3L·mol^-1·cm^-1）．奎尼丁在浓度10-250mg·L^-1范围内呈线性关系，检测限5mg·L^-1，r=0．9991．该方法用于硫酸奎尼丁片剂中奎尼丁含量的测定,5次测定的相对标准偏差为1．9％～2．6％，回收率为98．7％～99．6％．该方法简易、快速、灵敏度较高，可用于药物中奎尼丁的测定．

A new spectrophotometric method for the determination of quinidine was developed based on the charge-transfer reaction with micelle-sensitized. The absorption of the charge-transfer complex formed by quinidine and chloranilic acid was remarkably enhanced by Hexadecyltrimethylammonium bromide （CTAB） micellarsystem. The apparent molar absorptivity of quinidine complex （ ε = 2.41 × 10^3 L · mol^-1·cm^-1 at λ530 nm） raised 50% than that of non-micellar system. The linear range was 10 - 250 mg/L with a detection limit of 5 mg/ L（ r = 0.999 1 ）. Quinidine in tablets was successfully determined by this method with the recovery of 98.7% - 99.6%. Relative standard deviation was 1.9% - 2.6% （ n =5 ）.